HCID 10012515, compound → HCID 22342827, compound

HRID 584170Notes

Reaction equation

HRID 584170 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5](/[CH:7]=[CH:8]/[C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:4]=[CH:3]1>O1CCCC1.[Pd]>[CH3:1][N:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:4]=[CH:3]1

Participants

4

Reactant 1

HCID 10012515HCID 10012515, compound

Product 1

HCID 22342827HCID 22342827, compoundYield 104%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of ethyl (E)-3-(1-methyl-1H-imidazol-4-yl)acrylate (2.5 g) in tetrahydrofuran (100 ml) was hydrogenated over 10% palladium activated carbon (0.2 g) at room temperature under 2 atmospheric pressure. After removal of catalyst by filtration through Celite pad, the filtrate was concentrated under reduced pressure to give ethyl 3-(1-methyl-1H-imidazol-4-yl)propionate (2.63 g).

Workup

  1. customAfter removal of catalyst
  2. filtrationby filtration through Celite pad
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-54437d5a158441fa907f050c1ce2a195
Source dataset
uspto-grants-2005_08
Patent number
US06924278B2

Reaction notes

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