Hydrazine hydrate (1:1) → HCID 22342720, compound

HRID 584216Notes

Reaction equation

HRID 584216 reaction equation
C([N:4]1[CH2:9][C:8](=[O:10])[NH:7][CH:6]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[C:13]=2[O:20][CH3:21])[C:5]1=[O:22])(=O)C.O.NN>O1CCCC1>[CH3:21][O:20][C:13]1[C:14]([O:18][CH3:19])=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][CH:6]1[NH:7][C:8](=[O:10])[CH2:9][NH:4][C:5]1=[O:22]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 223429021-Acetyl-3-(2,3-dimethoxybenzyl)-2,5-piperazinedione

Product 1

HCID 22342720HCID 22342720, compoundYield 65.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of 1-acetyl-3-(2,3-dimethoxybenzyl)-2,5-piperazinedione (2.49 g) in tetrahydrofuran (38 ml) was added hydrazine monohydrate (0.43 ml) at room temperature and the mixture was stirred at the same temperature for 30 minutes. The resulting precipitates were collected by filtration and washed with tetrahydrofuran to give powders of 3-(2,3-dimethoxybenzyl)-2,5-piperazinedione (1.40 g)

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. washwashed with tetrahydrofuran

Sources & evidence

ORD record
ord-b5179d2c76624ac1b6a432dff7d2ee0a
Source dataset
uspto-grants-2005_08
Patent number
US06924278B2

Reaction notes

Loading…