HRID584317

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID8857

Ethyl acetate

C4H8O2

$结构：CCCc1cc(C2(CC)OCCO2)ccc1-c1cc(/C=C\c2ccc(C(=O)OC)c(C(=O)OC)c2)ccc1C$

HCID69792352

未命名化合物

PRODUCTS

生成物

结构：CCCc1cc(C2(CC)OCCO2)ccc1-c1cc(CCc2ccc(C(=O)OC)c(C(=O)OC)c2)ccc1C

HCID22345596

未命名化合物

收率 93%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

700 mg (1.3 mmol) of dimethyl 4-{(Z)-2-[4′-(2-ethyl[1,3]dioxolan-2-yl)-6-methyl-2′-propylbiphenyl-3-yl]vinyl}phthalate are placed in 15 ml of methanol, 15 ml of ethyl acetate and 1 ml of triethylamine in a reactor. The reaction medium is degassed and 100 mg of palladium-on-charcoal (10%) and hydrogen to a pressure of 3.5 bar at 80° C. are added. The reaction medium is filtered and evaporated to give 640 mg (93%) of the expected product in the form of an oil.

WORKUP

后处理

customThe reaction medium is degassed
addition100 mg of palladium-on-charcoal (10%) and hydrogen to a pressure of 3.5 bar at 80° C. are added
filtrationThe reaction medium is filtered
customevaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-12653ca7e90d47a18dcad1b475b8cba1
来源数据集: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06924400B2
来源说明: uspto-grants-2005_08

反应 SMILES

[CH2:1]([C:3]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[C:16](/[CH:21]=[CH:22]\[C:23]4[CH:24]=[C:25]([C:33]([O:35][CH3:36])=[O:34])[C:26](=[CH:31][CH:32]=4)[C:27]([O:29][CH3:30])=[O:28])[CH:15]=3)=[C:10]([CH2:37][CH2:38][CH3:39])[CH:9]=2)[O:7][CH2:6][CH2:5][O:4]1)[CH3:2].C(OCC)(=O)C.C(N(CC)CC)C>CO>[CH2:1]([C:3]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[C:16]([CH2:21][CH2:22][C:23]4[CH:24]=[C:25]([C:33]([O:35][CH3:36])=[O:34])[C:26](=[CH:31][CH:32]=4)[C:27]([O:29][CH3:30])=[O:28])[CH:15]=3)=[C:10]([CH2:37][CH2:38][CH3:39])[CH:9]=2)[O:4][CH2:5][CH2:6][O:7]1)[CH3:2]