Methyl iodide → HCID 9888471, compound

HRID 584653Notes

Reaction equation

HRID 584653 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7]([CH:13]([CH3:15])[CH3:14])[C:6]([S:16][C:17]1[NH:21][C:20]([C:22]([F:25])([F:24])[F:23])=[N:19][N:18]=1)=[N:5]2.[CH2:26](N(CC)CC)C.IC>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7]([CH:13]([CH3:15])[CH3:14])[C:6]([S:16][C:17]1[N:21]([CH3:26])[C:20]([C:22]([F:23])([F:24])[F:25])=[N:19][N:18]=1)=[N:5]2

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 8471TriethylamineHCID 178439935HCID 178439935, compound

Product 1

HCID 9888471HCID 9888471, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the above 6,7-dichloro-2-isopropyl-3-(5-trifluoromethyl-4H-1,2,4-triazol-3-ylsulfanyl)quinoxaline (78 mg, 0.19 mmol) in tetrahydrofuran (5 ml) was added triethylamine (0.05 ml, 0.38 mmol) followed by addition of iodomethane (0.02 ml, 0.29 mmol). The reaction was stirred under nitrogen overnight at room temperature. Purification by flash column chromatography using ethyl acetate:hexanes 1:10 afforded the title compound.

Workup

  1. customPurification by flash column chromatography

Sources & evidence

ORD record
ord-d8bba3dacbb3480b88d2a53697da0ae9
Source dataset
uspto-grants-2005_08
Patent number
US06927214B1

Reaction notes

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