反应详情

6,7-Difluoro-3-methyl-1H-quinoxalin-2-one (2 g, prepared from 4,5-difluoro-1,2-phenylene-diamine and pyruvic acid according to general procedure (A), step 1) was mixed with POCl3 (20 ml) and 4-dimethylaminopyridine (10 mol %) and the mixture was refluxed for 2 hours. The mixture was allowed to cool and poured onto ice (300 ml), filtered and washed with water to afford the title compound.

1. temperaturethe mixture was refluxed for 2 hours
2. temperatureto cool
3. additionpoured onto ice (300 ml)
4. filtrationfiltered
5. washwashed with water