Methanesulfinic acid → HCID 9862981, compound

HRID 584663Notes

Reaction equation

HRID 584663 reaction equation
Cl[C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10][C:9]2[C:4](=[CH:5][C:6]([Cl:17])=[C:7]([Cl:16])[CH:8]=2)[N:3]=1.[CH3:18][S:19]([OH:21])=[O:20].[Na]>CN(C=O)C>[Cl:16][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[Cl:17])[N:3]=[C:2]([S:19]([CH3:18])(=[O:21])=[O:20])[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10]2

Participants

5

Reactant 3

HCID 87251Methanesulfinic acidHCID 5360545SodiumHCID 223410732,6,7-Trichloro-3-(trifluoromethyl)quinoxaline

Product 1

HCID 9862981HCID 9862981, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2,6,7-trichloro-3-trifluoromethylquinoxaline (64 mg, 0.2 mmol) in DMF (1 ml) was added methanesulfinic acid, sodium salt (43 mg, 0.4 mmol). The reaction mixture was stirred at room temperature overnight, then it was partitioned between ethyl acetate and water. The organic layer was separated and concentrated to an oil. This oil was further purified by column chromatography (ethyl acetate:hexanes 1:3) to yield the title compound as a white solid.

Workup

  1. customit was partitioned between ethyl acetate and water
  2. customThe organic layer was separated
  3. concentrationconcentrated to an oil
  4. customThis oil was further purified by column chromatography (ethyl acetate:hexanes 1:3)

Sources & evidence

ORD record
ord-0550dabd66cb443ab3c91089aeceef56
Source dataset
uspto-grants-2005_08
Patent number
US06927214B1

Reaction notes

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