反应详情

A mixture of 1,5-bis(4-methoxyphenyl)-3-(methylsulfinyl)-1H-1,2,4-triazole (152 mg, 0.443 mmol) and m-chloroperbenzoic acid (115 mg, 0.664 mmol) in dichloromethane (1.5 mL) was stirred at room temperature for 6 hours. Dichloromethane and sat. sodium bicarbonate solution were poured into the mixture and the organic layer was separated. The aqueous layer was extracted with dichloromethane. A combined organic layer was washed with sat. sodium bicarbonate solution and brine and dried over magnesium sulfate. The solvent was removed under reduced pressure. The residue was triturated with diisopropyl ether and the precipitate was isolated by filtration, washed with diisopropyl ether, and dried in vacuo to give 1,5-bis(4-methoxyphenyl)-3-(methylsulfonyl)-1H-1,2,4-triazole (130 mg, 81.7% yield).

1. customthe organic layer was separated
2. extractionThe aqueous layer was extracted with dichloromethane
3. washA combined organic layer was washed with sat. sodium bicarbonate solution and brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was removed under reduced pressure
6. customThe residue was triturated with diisopropyl ether
7. customthe precipitate was isolated by filtration
8. washwashed with diisopropyl ether
9. customdried in vacuo