Oxalyl chloride → HCID 22341459, compound

HRID 584900Notes

Reaction equation

HRID 584900 reaction equation
C[CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]([CH3:29])[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:22])[CH:14]=2)=[CH:9][CH:8]=1)[C:3](O)=[O:4].C(Cl)(=O)C([Cl:33])=O>ClCCl>[CH3:29][N:20]([CH2:19][C:15]1[CH:14]=[C:13]([C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH2:2][C:3]([Cl:33])=[O:4])=[CH:8][CH:9]=2)[CH:18]=[CH:17][CH:16]=1)[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:22]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 10157037HCID 10157037, compound

Product 1

HCID 22341459HCID 22341459, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

By reacting 1.6 g (4.1 mmol) of 2-methyl-3-(3′-{[methyl-(1-phenylmethanoyl)amino]methyl}biphenyl-4-yl)propionic acid with 390 μl (4.5 mmol) of oxalyl chloride in dichloromethane, and after evaporation, 1.7 g (100%) of 3-(3′-{[methyl-(1-phenylmethanoyl)-amino]methyl}biphenyl-4-yl)propionyl chloride are obtained.

Workup

  1. customafter evaporation, 1.7 g (100%) of 3-(3′-{[methyl-(1-phenylmethanoyl)-amino]methyl}biphenyl-4-yl)propionyl chloride
  2. customare obtained

Sources & evidence

ORD record
ord-61cd9081043c4ba5be44c4caa783a085
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

Loading…