HCID 90914186, compound → HCID 10297891, compound

HRID 584928Notes

Reaction equation

HRID 584928 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH2:30][CH2:31][CH3:32])[C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1>C(OCC)(=O)C.CN(C)C=O>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH2:30][CH2:31][CH3:32])[C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:28])[CH3:27])[CH:16]=3)=[CH:13][CH:14]=2)[S:3]1

Participants

4

Reactant 1

HCID 90914186HCID 90914186, compound

Product 1

HCID 10297891HCID 10297891, compoundYield 10%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

In a manner similar to that of Example 1(g), starting with 600 mg (1.3 mmol) of tert-butyl [4′-(2,4-dioxothiazolidin-5-ylidenemethyl)biphenyl-3-ylmethyl]-propylcarbamate in 7 ml of ethyl acetate and 7 ml of dimethylformamide, 50 mg (10%) of the desired product are obtained.

Sources & evidence

ORD record
ord-fc0cef1e787c4d9c956022953194c4de
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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