HCID 69792650, compound → HCID 69792812, compound

HRID 584984Notes

Reaction equation

HRID 584984 reaction equation
[C:1]([N:9]([CH2:11][C:12]1[CH:13]=[C:14]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]=[C:25]([CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[C:26]([O:28][CH3:29])=[O:27])=[CH:20][CH:19]=2)[CH:15]=[CH:16][CH:17]=1)[CH3:10])(=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]>C(OCC)(=O)C.[Pd]>[C:1]([N:9]([CH2:11][C:12]1[CH:13]=[C:14]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[C:26]([O:28][CH3:29])=[O:27])=[CH:20][CH:19]=2)[CH:15]=[CH:16][CH:17]=1)[CH3:10])(=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

4

Reactant 1

HCID 69792650HCID 69792650, compound

Product 1

HCID 69792812HCID 69792812, compoundYield 77.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In a manner similar to that of Example 1(g), starting with 1.70 g (3.5 mmol) of methyl ethyl 2-{3′-[(heptanoylmethylamino)methyl]biphenyl-4-ylmethylene}succinate and 170 mg (10% by mass) of 10% palladium-on-charcoal in 20 ml of ethyl acetate, 1.30 g (77%) of the expected product are obtained.

Sources & evidence

ORD record
ord-ab830c4f12e549299801950e0ccf346c
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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