Hydrochloric Acid → HCID 22340319, compound

HRID 585304Notes

Reaction equation

HRID 585304 reaction equation
[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:14]C(=O)C)[CH:10]=2)[N:5]=1.Cl>>[ClH:2].[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:14])[CH:10]=2)[N:5]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22340304HCID 22340304, compound

Product 1

HCID 22340319HCID 22340319, compoundYield 192.6%

Conditions

Temperature
100 °C

Procedure

To the N-[2-(chloromethyl)-6-quinolinyl]acetamide hydrochloride (900 mg, 3.32 mmol) obtained in Reference Example 6 was added 5N hydrochloric acid (17 ml), and the mixture was stirred at 100° C. for 2 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was washed with tetrahydrofuran to obtain the titled compound (849 mg) as powders.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe resulting residue was washed with tetrahydrofuran

Sources & evidence

ORD record
ord-7e9601225fc44cf2886c0c71f3a0d6c6
Source dataset
uspto-grants-2005_08
Patent number
US06930185B2

Reaction notes

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