HRID585488

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID141120

N-(6-Bromohexyl)phthalimide

C14H16BrNO2

结构：COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC

HCID68878852

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2=NN(C3CCN(CCCCCCN4C(=O)c5ccccc5C4=O)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC

HCID69794712

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A mixture of 6 mmol of 2-(6-bromo-hexyl)-isoindole-1,3-dione, 6 mmol of compound 5c and 3 g of potassium carbonate in 50 ml of dimethylformamide is stirred for 18 h at RT. After evaporating the solvent, the residue is partitioned between water and ethyl acetate. The organic layer is dried over magnesium sulfate and evaporated. The residue is purified by chromatography (ethyl acetate:hexane/4:1). M. p. 39-44° C.

WORKUP

后处理

customAfter evaporating the solvent
customthe residue is partitioned between water and ethyl acetate
dry with materialThe organic layer is dried over magnesium sulfate
customevaporated
customThe residue is purified by chromatography (ethyl acetate:hexane/4:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c666d165ed1d48ce93fa309741bffbcd
来源数据集: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06933296B2
来源说明: uspto-grants-2005_08

反应 SMILES

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([C:29]2[C@@H:38]3[C@@H:33]([CH2:34][CH:35]=[CH:36][CH2:37]3)[C:32](=[O:39])[N:31]([CH:40]3[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]3)[N:30]=2)[CH:24]=[CH:25][C:26]=1[O:27][CH3:28].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:19][O:20][C:21]1[CH:22]=[C:23]([C:29]2[C@@H:38]3[C@@H:33]([CH2:34][CH:35]=[CH:36][CH2:37]3)[C:32](=[O:39])[N:31]([CH:40]3[CH2:45][CH2:44][N:43]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]4[C:16](=[O:17])[C:15]5[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=5)[C:9]4=[O:18])[CH2:42][CH2:41]3)[N:30]=2)[CH:24]=[CH:25][C:26]=1[O:27][CH3:28]