Hydrochloric Acid → HCID 22337082, compound

HRID 585515Notes

Reaction equation

[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:11]=2[C:12](=[O:43])[N:13]([CH2:20][C:21]2[CH:22]=[C:23]([C:27]4[CH:32]=[CH:31][C:30]([F:33])=[C:29]([CH2:34][NH:35]C(=O)OC(C)(C)C)[CH:28]=4)[CH:24]=[CH:25][CH:26]=2)[C:14]3=[O:19])=[O:8])=[CH:4][CH:3]=1.Cl>>[ClH:1].[NH2:35][CH2:34][C:29]1[CH:28]=[C:27]([C:23]2[CH:24]=[CH:25][CH:26]=[C:21]([CH2:20][N:13]3[C:12](=[O:43])[C:11]4[C:15](=[CH:16][CH:17]=[CH:18][C:10]=4[NH:9][C:7]([C:5]4[S:6][C:2]([Cl:1])=[CH:3][CH:4]=4)=[O:8])[C:14]3=[O:19])[CH:22]=2)[CH:32]=[CH:31][C:30]=1[F:33]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86595792HCID 86595792, compound

Product 1

HCID 22337082HCID 22337082, compound

Procedure

Starting with tert-butyl {3′-[(4-{[(5-chloro-2-thienyl)carbonyl]amino}-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-4-fluoro[1,1′-biphenyl]-3-yl}methylcarbamate, by treating the crude product with etheral hydrochloric acid solution, it is possible to obtain N-(2-{[3′-(aminomethyl)-4′-fluoro[1,1′-biphenyl]-3-yl]methyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-5-chloro-2-thiophenecarboxamide hydrochloride.

Sources & evidence

ORD record: ord-3319f691a9ca49e48d74a96f75029580
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06933295B2

Reaction notes

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