Potassium Carbonate → 4-(Tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid
Reaction equation
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:10][CH2:11][S:12]2)=[CH:7][C:6]=1[CH3:23])=[O:4].C(=O)([O-])[O-].[K+].[K+]>>[C:19]([O:18][C:16]([NH:15][CH:9]1[C:8]2[C:13](=[CH:14][C:5]([C:3]([OH:4])=[O:2])=[C:6]([CH3:23])[CH:7]=2)[S:12][CH2:11][CH2:10]1)=[O:17])([CH3:22])([CH3:20])[CH3:21]Participants
3
Procedure
By a similar reaction operation as in Starting Material Synthetic Example 6 using 4-(tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid methyl ester (2.80 g) and potassium carbonate (3.44 g), the objective 4-(tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid (2.41 g) was obtained as colorless crystals.
Sources & evidence
- ORD record
- ord-ef19413c7f024b5aa89f4246e42cbfa8
- Source dataset
- uspto-grants-2005_08
- Patent number
- US06933305B2
Reaction notes
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