反应详情

温度

45 °C

Pantoprazole freebase (25 grams) was dissolved in a solution of ethyl acetate (50 ml) and aqueous sodium hydroxide solution (2.7 grams in 5 ml of water) and stirred at a temperature of 40-50° C. till the clear solution results. Methyl tertiary butyl ether (250 ml) was added to the reaction mixture and stirred for about 3-4 hours to crystallize the solid mass. The separated solid mass was filtered, washed with methyl tertiary butyl ether (50 ml) and suck dried under vacuum. The wet solid was further dried at a temperature of 40-50° C. to afford crystalline Form-I of Pantoprazole sodium sesquihydrate.

1. customresults
2. stirringstirred for about 3-4 hours
3. customto crystallize the solid mass
4. filtrationThe separated solid mass was filtered
5. washwashed with methyl tertiary butyl ether (50 ml)
6. customsuck dried under vacuum
7. customThe wet solid was further dried at a temperature of 40-50° C.