反应详情

温度

-10 °C

To 3-(3,5-difluoropyridin-2-yl)-4-fluorophenylamine was added 1,4-dioxane (5 ml) and 48% aqueous hydrogen bromide (15 ml). The solution was cooled to −10° C., and a solution of sodium nitrite (0.252 g) in water (1 ml) was added dropwise with stirring to maintain an internal temperature below −5° C. The mixture was then stirred for a further 1 h at 0 to −5° C., then a solution of copper(I) bromide (1.283 g) in 48% aqueous hydrogen bromide (5 ml) was added slowly with stirring to maintain a reaction temperature below 10° C. The mixture was then stirred at 10° C. for 1 h, room temperature for a further hour, and then heated at 35° C. for 0.5 h. The reaction mixture was then cooled in an ice bath and 4 N aqueous sodium hydroxide (41 ml) was added slowly with stirring, followed by 30% aqueous ammonia (15 ml). The resulting mixture was extracted with ethyl acetate. The organic extracts were evaporated and the residue subjected to chromatography (silica gel, 10% Et2O/isohexane) to afford 2-(5-bromo-2-fluorophenyl)-3,5-difluoropyridine (0.48 g) as a colourless solid: MS (ES+) m/z 288, 290 [M+H]+.

1. temperatureto maintain an internal temperature below −5° C
2. stirringThe mixture was then stirred for a further 1 h at 0 to −5° C.
3. stirringwith stirring
4. temperatureto maintain a reaction temperature below 10° C
5. stirringThe mixture was then stirred at 10° C. for 1 h, room temperature for a further hour
6. temperatureheated at 35° C. for 0.5 h
7. temperatureThe reaction mixture was then cooled in an ice bath
8. stirringwith stirring
9. extractionThe resulting mixture was extracted with ethyl acetate
10. customThe organic extracts were evaporated