HCID 22329559, compound → HCID 22329523, compound

HRID 586324Notes

Reaction equation

HRID 586324 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:9]=2[F:17])=[N:6][CH:7]=1>C(O)C.ClCCl.[Pt](=O)=O>[F:17][C:9]1[CH:10]=[CH:11][C:12]([NH2:14])=[CH:13][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][N:6]=1

Participants

5

Reactant 1

HCID 22329559HCID 22329559, compound

Product 1

HCID 22329523HCID 22329523, compound

Reagents, catalysts & solvents 3

HCID 345198Adams' catalystCatalystHCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-fluoro-2-(2-fluoro-5-nitrophenyl)pyridine (1.23 g) in ethanol (70 ml) and dichloromethane (30 ml) was added platinum(IV) oxide (150 mg) and the mixture shaken on a Parr hydrogenation apparatus under an atmosphere of hydrogen at 45 psi for 1 h. Filtration and evaporation of the filtrate afforded 4-fluoro-3-(5-fluoropyridin-2-yl)phenylamine: MS (ES+) m/z 207.

Workup

  1. filtrationFiltration and evaporation of the filtrate

Sources & evidence

ORD record
ord-aa322caf7aa7454fa605b46ef0b2cd89
Source dataset
uspto-grants-2005_08
Patent number
US06936608B2

Reaction notes

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