Hydrochloric Acid → HCID 9800603, compound

HRID 586439Notes

Reaction equation

HRID 586439 reaction equation
[ClH:1].[CH2:2]([CH:4]([CH2:33][CH3:34])[CH:5]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([CH:20]2[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]2)=[O:19])=[CH:13][CH:12]=1)[N:6]1[CH:10]=[CH:9][N:8]=[CH:7]1)[CH3:3].[OH-].[Na+]>CCOC(C)=O>[ClH:1].[CH2:33]([CH:4]([CH2:2][CH3:3])[CH:5]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([CH:20]2[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2)=[O:19])=[CH:13][CH:12]=1)[N:6]1[CH:10]=[CH:9][N:8]=[CH:7]1)[CH3:34]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22335531HCID 22335531, compound

Product 1

HCID 9800603HCID 9800603, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

HCl conc. (3.6 ml) was added at RT to a mixture of (±)-1,1-dimethylethyl 4-[[[4-[2-ethyl-1-(1H-imidazol-1-yl)butyl]phenyl]amino]carbonyl]- 1-piperidinecarboxylate (0.0032 mol) in EtOAc (30 ml). The mixture was stirred at RT for 4 hours, then basified with a concentrated NaOH solution and extracted with EtOAc and then CH2Cl2. The organic layer was separated, dried, filtered and the solvent was evaporated. The residue (1 g) was converted into the hydrochloric acid salt (1:1) in 2-propanol. The precipitate was filtered off and dried, yielding 0.85 g (68%) (±)-N-[4-[2-ethyl-1-(1H-imidazol-1-yl)butyl]-phenyl]-4-piperidinecarboxamide monohydrochloride (compound 57).

Workup

  1. extractionextracted with EtOAc
  2. customThe organic layer was separated
  3. customdried
  4. filtrationfiltered
  5. customthe solvent was evaporated
  6. filtrationThe precipitate was filtered off
  7. customdried

Sources & evidence

ORD record
ord-dc3fe26c6e3948cdbd5073f699e9bd62
Source dataset
uspto-grants-2005_08
Patent number
US06936626B2

Reaction notes

Loading…