Tert-Butylamine → N-tert-butyl-6-chloronicotinamide

HRID 586805Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[C:11]([NH2:15])([CH3:14])([CH3:13])[CH3:12]>>[C:11]([NH:15][C:6]([C:5]1[CH:4]=[N:3][C:2]([Cl:1])=[CH:10][CH:9]=1)=[O:8])([CH3:14])([CH3:13])[CH3:12]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 792226-Chloronicotinic acid

Product 1

HCID 11816697N-tert-butyl-6-chloronicotinamide

Procedure

The title compound was prepared by the same method as that described in Example 26, using 6-chloronicotinic acid and t-butylamine.

Sources & evidence

ORD record: ord-c2b070910fa5485fb8418c23aa1e0295
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06936736B2

Reaction notes

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