Sodium Hydroxide → Tricalcium Phosphate

HRID 587104Notes

Reaction equation

HRID 587104 reaction equation
[Cl-].[Ca+2:2].[Cl-].[P:4]([O-:8])([O-:7])([OH:6])=[O:5].[OH-].[Na+]>>[P:4]([O-:8])([O-:7])([O-:6])=[O:5].[Ca+2:2].[P:4]([O-:8])([O-:7])([O-:6])=[O:5].[Ca+2:2].[Ca+2:2]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 3681305Hydrogen phosphateHCID 5284359Calcium Chloride

Product 1

HCID 24456Tricalcium Phosphate

Procedure

An aqueous solution of calcium chloride (18 mM) was added, dropwise and under magnetic stirring, to an aqueous solution on dibasic hydrogen phosphate (10.8 mM). The pH of both solutions was adjusted beforehand to 9.5 with NaOH. CaP NPs were obtained by filtration of the suspension through a 0.22 μm filter. CaP NPs were stored at 4° C. before use. CaP/ZOL-NPs complexes (CaPZ NPs) were prepared by mixing a CaP NPs dispersion with an aqueous solution of ZOL at different ZOL concentrations (10 mg/ml of ZOL in water or 50 mg/ml of ZOL in phosphate buffer at pH 9.5), at a volume ratio of 50:1.

Workup

  1. customCaP NPs
  2. customwere obtained by filtration of the suspension through a 0.22 μm
  3. filtrationfilter
  4. customCaP NPs
  5. customwere stored at 4° C. before use
  6. customCaP/ZOL-NPs complexes (CaPZ NPs) were prepared
  7. additionby mixing a CaP NPs dispersion with an aqueous solution of ZOL
  8. concentrationat different ZOL concentrations (10 mg/ml of ZOL in water or 50 mg/ml of ZOL in phosphate buffer at pH 9.5)

Sources & evidence

ORD record
ord-f3d8a68c81474492834b414a03b1058d
Source dataset
uspto-grants-2016_01
Patent number
US09226897B2

Reaction notes

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