Sodium Hydroxide → Tricalcium Phosphate

HRID 587105Notes

Reaction equation

HRID 587105 reaction equation
[Cl-].[Ca+2:2].[Cl-].[P:4]([O-:8])([O-:7])([OH:6])=[O:5].[OH-].[Na+]>P([O-])([O-])([O-])=O>[P:4]([O-:8])([O-:7])([O-:6])=[O:5].[Ca+2:2].[P:4]([O-:8])([O-:7])([O-:6])=[O:5].[Ca+2:2].[Ca+2:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 3681305Hydrogen phosphateHCID 5284359Calcium Chloride

Product 1

HCID 24456Tricalcium Phosphate

Reagents, catalysts & solvents 1

HCID 1061PhosphateSolvent

Procedure

An aqueous solution of calcium chloride (18 mM) was added, dropwise and under magnetic stirring, to an aqueous solution on dibasic hydrogen phosphate (10.8 mM). The pH of both solutions was adjusted beforehand to 9.5 with NaOH. CaP NPs were obtained by filtration of the suspension through a 0.22 μm filter. CaP NPs were stored at 4° C. before use. CaP/ZOL-NPs complexes (CaPZ NPs) were prepared by mixing a CaP NPs dispersion with an aqueous solution of (50 mg/ml of ZOL in phosphate buffer at pH 9.5), at a volume ratio of 50:1.

Workup

  1. customCaP NPs
  2. customwere obtained by filtration of the suspension through a 0.22 μm
  3. filtrationfilter
  4. customCaP NPs
  5. customwere stored at 4° C. before use
  6. customCaP/ZOL-NPs complexes (CaPZ NPs) were prepared

Sources & evidence

ORD record
ord-9fb1ff1cb2d94f1da5086a474289cc48
Source dataset
uspto-grants-2016_01
Patent number
US09226897B2

Reaction notes

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