Methanol → HCID 68476360, compound

Temperature

22 °C

To 331 mg (0.839 mmol) of 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-(methyl(phenethyl)amino)pentanenitrile in 8.3 mL of benzene was added 226 mg (1.01 mmol) of palladium(II)acetate and the mixture was stirred for 72 h at 22° C. under nitrogen. The solution was transferred into a pressure flask, 10 mL of methanol was added and the mixture was treated with carbon monoxide at 40 psi for 24 h. After addition of 175 μL (1.26 mmol) of triethylamine, the mixture was filtered through a pad of celite and evaporated to give a crude mixture of 3au and 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-(methyl(phenethyl)amino)pentanenitrile. In order to afford purification, a solution of 57 mg of the crude product was dissolved in 1 mL of methanol and treated with 63 μL of 10 N NaOH. After stirring for 1 h at 22° C., an additional 1264 of 10 N NaOH and 2 mL of methanol was added. The solution was heated to 50° C. then cooled to 22° C., evaporated and partitioned between ether and 0.5 N NaOH. The aqueous layer was acidified to about pH 6 with 12 N HCl then extracted with ethyl acetate (3×). The combined organic layers were dried (Na2SO4) and evaporated to give 2-(2-((4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl)(methyl)amino)ethyl)benzoic acid. The carboxylic acid was esterified by treating with 44 mg (0.24 mmol) of carbonyldiimidazole in 1 mL of THF for 3 h at 22° C. followed by addition of 8 mL of methanol and continued stirring for about 16 hours at 22° C. The solvent was evaporated and the residue was purified by flash chromatography on silica gel, eluting first with dichloromethane and then gradually increasing to 3% methanol/dichloromethane to give 3au. MS found M+H=453. Substitution of the ester group in the indicated ortho-position of the phenyl ring was confirmed by 1H NMR analysis.

1. customThe solution was transferred into a pressure flask
2. filtrationthe mixture was filtered through a pad of celite
3. customevaporated
4. customto give a crude
5. customIn order to afford
6. custompurification
7. dissolutiona solution of 57 mg of the crude product was dissolved in 1 mL of methanol
8. additiontreated with 63 μL of 10 N NaOH
9. stirringAfter stirring for 1 h at 22° C.
10. additionan additional 1264 of 10 N NaOH and 2 mL of methanol was added
11. temperatureThe solution was heated to 50° C.
12. temperaturethen cooled to 22° C.
13. customevaporated
14. custompartitioned between ether and 0.5 N NaOH
15. extractionthen extracted with ethyl acetate (3×)
16. dry with materialThe combined organic layers were dried (Na2SO4)
17. customevaporated

ORD record

ord-1d8b4b29db254a758a8b46ccc5ffccc6

Source dataset

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09227918B2