反应详情

温度

0 °C

6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine (115 mg, 0.261 mmol) was taken up in THF (2.6 ml) and cooled to 0° C. DIPEA (228 μl, 1.304 mmol) followed by acetyl chloride (93 μl, 1.304 mmol) was added. The mixture was allowed to stir, reaching room temperature overnight. EtOAc and saturated NH4Cl were added. The products were extracted into EtOAc (3×). The combined organic layers were washed with brine, dried over Mg SO4, and concentrated in vacuo to give N-(6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)acetamide (48B). Reaction products were carrried forward without purification. MS: [M+H]+ m/z 483.

1. additionwas added
2. extractionThe products were extracted into EtOAc (3×)
3. washThe combined organic layers were washed with brine
4. dry with materialdried over Mg SO4
5. concentrationconcentrated in vacuo