反应详情

温度

0 °C

6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine-4-carboxylic acid (Intermediate 36B, 440 mg, 0.936 mmol) was taken up in DCM (9.32 ml). DMF (93 n1) was added and the reaction was cooled to 0° C. Oxalyl chloride (164 μl, 1.873 mmol) was added and the mixture was allowed to stir for 1 hr eventually reaching room temperature. The mixture was concentrated in vacuo and then further dried under high vacuum. The residue was carried forward without further purification. MS: [M+H]+ m/z 484 (Methyl ester formed LCMS, sample prepared in MeOH).

1. customeventually reaching room temperature
2. concentrationThe mixture was concentrated in vacuo
3. customfurther dried under high vacuum
4. customThe residue was carried forward without further purification
5. customMS: [M+H]+ m/z 484 (Methyl ester formed LCMS, sample prepared in MeOH)