反应详情

64.3 mg (0.46 mmol) of potassium carbonate are added to a mixture, prepared under argon, of 65.1 mg (0.31 mmol) of (3R)-quinuclidine-3-carbonyl chloride hydrochloride (Example 5A) and 45.0 mg (0.15 mmol) of 4′-amino-N-isopropylbiphenyl-4-sulfonamide (Example 12A) in 2.2 ml of a 10:1 mixture of dioxane and DMF. After 18 h at 100° C., the reaction mixture is concentrated in vacuo. The residue is dissolved in water and acetonitrile and purified by preparative HPLC. The product fractions are concentrated, mixed with 5 ml of a 2:1 mixture of acetonitrile and 1 N hydrochloric acid, again concentrated and dried under high vacuum. 21 mg (29.2% of theory) of the title compound are obtained.

1. concentrationthe reaction mixture is concentrated in vacuo
2. dissolutionThe residue is dissolved in water
3. customacetonitrile and purified by preparative HPLC
4. concentrationThe product fractions are concentrated
5. additionmixed with 5 ml of a 2:1 mixture of acetonitrile and 1 N hydrochloric acid
6. concentrationagain concentrated
7. customdried under high vacuum