Hydrochloric Acid → HCID 67395342, compound

HRID 588492Notes

Reaction equation

C([S@@]([NH:7][C@@H:8]([C:10]1[S:14][C:13]([C:15]([O-:17])=[O:16])=[CH:12][CH:11]=1)[CH3:9])=O)(C)(C)C.[ClH:18]>>[ClH:18].[NH2:7][C@@H:8]([C:10]1[S:14][C:13]([C:15]([OH:17])=[O:16])=[CH:12][CH:11]=1)[CH3:9]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86657333HCID 86657333, compound

Product 1

HCID 67395342HCID 67395342, compound

Conditions

Temperature: 60 °C

Procedure

To a vial containing 5-[(1R)-1-{[(S)-tert-butylsulfinyl]amino}ethyl]thiophene-2-carboxylate (0.050 g, 0.15 mmol) was added hydrochloric acid (3 mL, 12.0 mmol, 4.0 M of in 1,4-dioxane). This mixture was capped and heated at 60° C. for 2 h, after which it was evaporated to dryness to afford (R)-5-(1-aminoethyl)thiophene-2-carboxylic acid hydrochloride as a white solid. LC-MS: (FA) ES+ 172.

Workup

customThis mixture was capped
customafter which it was evaporated to dryness

Sources & evidence

ORD record: ord-c25802e7c3ab4658961beb1a22b0bba3
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09227951B2

Reaction notes

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