Sodium Iodide → HCID 90455791, compound

HRID 588910Notes

Reaction equation

HRID 588910 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]=[CH2:11].[Si]([C:16]([F:19])(F)[F:17])(C)(C)C.[Na+].[I-]>C1COCC1.CCCCCC>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]1[CH2:11][C:16]1([F:19])[F:17]

Participants

6

Reactant 3

HCID 5238Sodium IodideHCID 552549(Trifluoromethyl)trimethylsilaneHCID 90456012HCID 90456012, compound

Product 1

HCID 90455791HCID 90455791, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8058HexaneSolvent2×

Conditions

Temperature
80 °C

Procedure

The solution of 2-chloro-4-methoxy-1-vinylbenzene (290 mg, 1.72 mmol) in dry THF (4 mL) was degassed, and then TMS-CF3 and NaI were added. The mixture was stirred at 80° C. overnight. TLC (100% Hexane) showed the reaction as complete. The mixture was diluted with hexane (20 mL). The inorganic salt was removed by filtration. The filtrate was concentrate in vacuo. The residue was purified via Isolera One (Hexane=100%).

Workup

  1. customthe reaction as complete
  2. customThe inorganic salt was removed by filtration
  3. concentrationThe filtrate was concentrate in vacuo
  4. customThe residue was purified via Isolera One (Hexane=100%)

Sources & evidence

ORD record
ord-7a05b2e6b7874c4f9c5e1c48ee4d68dc
Source dataset
uspto-grants-2016_01
Patent number
US09227978B2

Reaction notes

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