Bromine → 2-Bromo-1-(1,3-thiazol-2-yl)ethan-1-one
Reaction equation
[Br:1]Br.[S:3]1[CH:7]=[CH:6][N:5]=[C:4]1[C:8](=[O:10])[CH3:9]>CC(O)=O>[Br:1][CH2:9][C:8]([C:4]1[S:3][CH:7]=[CH:6][N:5]=1)=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
Bromine (70 μL, 1 mmol) was added to a mixture of 1-(1,3-thiazol-2-yl)ethanone (200 mg, 2 mmol) in AcOH (5 mL). The reaction mixture was stirred at 100° C. for 30 min. and was concentrated under reduced pressure to give 2-bromo-1-(1,3-thiazol-2-yl)ethanone as an oil (100%) used as crude.
Workup
- concentrationwas concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-db14e5c46bff42a58ffb9bd26c288d77
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09227985B2
Reaction notes
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