HCID 131734455, compound → HCID 86299113, compound

HRID 589041Notes

Reaction equation

HRID 589041 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[C:16]3[O:15][CH2:14][CH:13]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:12]4[C:23]([N:25]5[CH2:30][CH2:29][N:28](C([O-])=O)[CH2:27][CH2:26]5)=[N:24][C:10]([C:11]=34)=[CH:9][CH:8]=2)=[C:5]([CH3:34])[O:4][N:3]=1>Cl>[CH3:1][C:2]1[C:6]([C:7]2[C:16]3[O:15][CH2:14][CH:13]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:12]4[C:23]([N:25]5[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]5)=[N:24][C:10]([C:11]=34)=[CH:9][CH:8]=2)=[C:5]([CH3:34])[O:4][N:3]=1

Participants

3

Reactant 1

HCID 131734455HCID 131734455, compound

Product 1

HCID 86299113HCID 86299113, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4-[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazine-1-carboxylate (Example 60) was stirred in 4 N HCl for 15 min. at room temperature and evaporated. Purification by preparative LCMS at pH 10 gave the desired compound which was isolated as the dihydrochloride salt. LCMS calc. for C24H26N5O2 (M+H)+: m/z=416.2. found: 416.2.

Workup

  1. customevaporated
  2. customPurification by preparative LCMS at pH 10

Sources & evidence

ORD record
ord-dbfb47e667d747459fd3d0b614af3529
Source dataset
uspto-grants-2016_01
Patent number
US09227985B2

Reaction notes

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