Water → HCID 178524935, compound

HRID 589209Notes

Reaction equation

HRID 589209 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[NH:8][C:9]([C:12]([O:14]C)=[O:13])=[N:10][N:11]=2)[CH2:3][CH2:2]1.[Li+].[OH-].O>C1COCC1>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[NH:8][C:9]([C:12]([OH:14])=[O:13])=[N:10][N:11]=2)[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 178499165HCID 178499165, compound

Product 1

HCID 178524935HCID 178524935, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 5-morpholino-4H-1,2,4-triazole-3-carboxylate (0.090 g, 0.398 mmols†) in THF (1 mL) was added 1 N LiOH (0.800 mL, 0.80 mmol) and H2O (1 mL). The reaction was stirred at rt for 12 h. The reaction mixture was concentrated and lypholized to get 5-morpholino-4H-1,2,4-triazole-3-carboxylic acid quantative yield and used as it is in next step.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-9db16ba7035240408afb55eb0ed88405
Source dataset
uspto-grants-2016_01
Patent number
US09227971B2

Reaction notes

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