Isopropylamine → Isopropylammonium 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

HRID 589289Notes

Reaction equation

HRID 589289 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:14]=[CH:13][C:6]2[S:7][C:8]([C:10]([OH:12])=[O:11])=[CH:9][C:5]=2[CH:4]=1.[CH:17]([NH2:20])([CH3:19])[CH3:18]>O1CCCC1>[F:16][C:2]([F:1])([F:15])[C:3]1[CH:14]=[CH:13][C:6]2[S:7][C:8]([C:10]([O-:12])=[O:11])=[CH:9][C:5]=2[CH:4]=1.[CH:17]([NH3+:20])([CH3:19])[CH3:18]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 27830435-(Trifluoromethyl)-1-benzothiophene-2-carboxylic acid

Product 1

HCID 70982169Isopropylammonium 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylateYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 300 mg of 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, 80 mg of isopropylamine and 10 ml of tetrahydrofuran was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 372 mg of isopropylammonium 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate (hereinafter referred to as “the present compound 7”).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c77e20fb3ae54471a8f6780dc5f15fec
Source dataset
uspto-grants-2016_01
Patent number
US09232792B2

Reaction notes

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