Fexofenadine Hydrochloride → Fexofenadine

HRID 589315Notes

Reaction equation

HRID 589315 reaction equation
[CH3:1][C:2]([C:35]([OH:37])=[O:36])([C:4]1[CH:5]=[CH:6][C:7]([CH:10]([OH:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20]([OH:33])([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:16][CH2:15]2)=[CH:8][CH:9]=1)[CH3:3].Cl>C1CCCCC1>[CH3:3][C:2]([C:35]([OH:37])=[O:36])([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([OH:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([C:20]([OH:33])([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:18][CH2:19]2)=[CH:6][CH:5]=1)[CH3:1]

Participants

4

Reactant 2

HCID 63002Fexofenadine HydrochlorideHCID 178435160HCID 178435160, compound

Product 1

HCID 3348Fexofenadine

Reagents, catalysts & solvents 1

HCID 8078CyclohexaneSolvent

Procedure

Cyclohexane is poured into the microencapsulation reactor. Then, under continuous stirring, fexofenadine HCl, ethylcellulose (EC) and polyethylene are added. The mixture is heated and then cooled down. Microcapsules are recovered, and then washed (one or more times), filtered, and dried over night (about 16 h) in a fume hood or in a hood at 40° C. The powder is sieved through a 300 μm opening sieve.

Workup

  1. temperatureThe mixture is heated
  2. temperaturecooled down
  3. customMicrocapsules are recovered
  4. washwashed (one or more times)
  5. filtrationfiltered
  6. customdried over night (about 16 h) in a fume hood
  7. customat 40° C
  8. filtrationThe powder is sieved through a 300 μm

Sources & evidence

ORD record
ord-0e6b7d98823d4d1ab0247764f0946649
Source dataset
uspto-grants-2016_01
Patent number
US09233105B2

Reaction notes

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