HRID589315

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl

HCID63002

Fexofenadine Hydrochloride

C32H40ClNO4

HCID178435160

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1

HCID3348

Fexofenadine

C32H39NO4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8078

Cyclohexane

C6H12

PROCEDURE

实验过程

Cyclohexane is poured into the microencapsulation reactor. Then, under continuous stirring, fexofenadine HCl, ethylcellulose (EC) and polyethylene are added. The mixture is heated and then cooled down. Microcapsules are recovered, and then washed (one or more times), filtered, and dried over night (about 16 h) in a fume hood or in a hood at 40° C. The powder is sieved through a 300 μm opening sieve.

WORKUP

后处理

temperatureThe mixture is heated
temperaturecooled down
customMicrocapsules are recovered
washwashed (one or more times)
filtrationfiltered
customdried over night (about 16 h) in a fume hood
customat 40° C
filtrationThe powder is sieved through a 300 μm

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0e6b7d98823d4d1ab0247764f0946649
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09233105B2
来源说明: uspto-grants-2016_01

反应 SMILES

[CH3:1][C:2]([C:35]([OH:37])=[O:36])([C:4]1[CH:5]=[CH:6][C:7]([CH:10]([OH:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20]([OH:33])([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:16][CH2:15]2)=[CH:8][CH:9]=1)[CH3:3].Cl>C1CCCCC1>[CH3:3][C:2]([C:35]([OH:37])=[O:36])([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([OH:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([C:20]([OH:33])([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:18][CH2:19]2)=[CH:6][CH:5]=1)[CH3:1]