2-Oxoglutaric Acid → HCID 118638662, compound

2-Ketoglutaric acid (98.5%, 1.484 g, 10.0 mmol) was suspended in 2-propanol (25 mL), cooled in ice and neutralized with a 40% aqueous solution of tetrabutylammonium hydroxide (5.9 mL, 9.0 mmol). The resulting solution was diluted with hexane (7 mL), dried in vacuo (below 30° C.), dissolved in a mixture of 2-propanol (15 mL) and hexane (5 mL) and dried as above to a viscous syrup (4.834 g). The residue was protected with argon, dissolved in N,N-dimethylacetamide (5 mL), and p-methoxybenzyl chloride (1.25 mL, 9.0 mmol) was added. The mixture was allowed to react at room temperature under argon protection for 65 h. An 0.8 M aqueous solution of phosphoric acid (40 mL) was added, the mixture was extracted with ethyl acetate, the organic layer was washed with 0.8 M phosphoric acid, with water, and dried. The crude monoester (2.266 g) was purified by flash chromatography (silica-gel, chloroform-ethyl acetate, 100:0 to 1:1, containing 0.2% of acetic acid) and crystallized from ethyl acetate-hexane. Yield of 3: 1.330 g (56%), 1H NMR (CDCl3) detected 60% of the open tautomer 3a and 40% of the cyclic tautomer 3b.

1. temperaturecooled in ice
2. customdried in vacuo (below 30° C.)
3. dissolutiondissolved in a mixture of 2-propanol (15 mL) and hexane (5 mL)
4. dry with materialdried as above to a viscous syrup (4.834 g)
5. dissolutiondissolved in N,N-dimethylacetamide (5 mL)
6. customto react at room temperature under argon protection for 65 h
7. extractionthe mixture was extracted with ethyl acetate
8. washthe organic layer was washed with 0.8 M phosphoric acid, with water
9. customdried
10. customThe crude monoester (2.266 g) was purified by flash chromatography (silica-gel, chloroform-ethyl acetate, 100:0 to 1:1, containing 0.2% of acetic acid)
11. customcrystallized from ethyl acetate-hexane

ORD record

ord-cfe1f7a1e7ce480da424516f85c8aae3

Source dataset

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09233163B2