反应详情

Phosphorous oxychloride (104 gm) was added slowly to 4-(4-hydroxypyrimidin-2-ylamino)benzonitrile (12 gm) at 0° C. and then heated to reflux for 1 hour. The solution was then cooled to room temperature, stirred for 30 minutes and filtered. The precipitated solid thus obtained was dissolved in isopropyl alcohol at 0 to 5° C. and stirred for 1 hour at 0 to 5° C. The solid obtained was collected by filtration and then dried to obtain 9.75 gm of 4-(4-chloropyrimidin-2-ylamino)benzonitrile.

1. temperatureheated
2. temperatureto reflux for 1 hour
3. filtrationfiltered
4. customThe precipitated solid thus obtained
5. stirringstirred for 1 hour at 0 to 5° C
6. customThe solid obtained
7. filtrationwas collected by filtration
8. customdried