3-Aminobenzoic Acid → HCID 56941310, compound

HRID 589711Notes

Reaction equation

HRID 589711 reaction equation
[Cl:1][C:2]1[C:10]2[S:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[C:7]([CH3:15])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20]([OH:22])=[O:21]>>[Cl:1][C:2]1[C:10]2[S:9][C:8]([S:11]([NH:16][C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20]([OH:22])=[O:21])(=[O:13])=[O:12])=[C:7]([CH3:15])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 74193-Aminobenzoic AcidHCID 587131497-Chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride2×

Product 1

HCID 56941310HCID 56941310, compoundYield 63%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 7-chloro-3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 6) (30 mg, 0.10 mmol) and 3-amino-benzoic acid (29 mg, 0.21 mmol) to afford 24 mg (63%) of the title compound. MS (ESI+) calcd for C16H12ClNO4S2 380.989627, found 380.989977.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-11696eb75131445f8527ab99d30b545e
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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