Lithium Hydroxide → HCID 56941312, compound

HRID 589716Notes

Reaction equation

HRID 589716 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:13][C:14]3[CH:15]=[C:16]([CH:22]=[CH:23][CH:24]=3)[C:17]([O:19]CC)=[O:18])(=[O:12])=[O:11])=[C:7]([CH3:25])[C:6]=2[CH:26]=1.[Li+].[OH-]>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:13][C:14]3[CH:15]=[C:16]([CH:22]=[CH:23][CH:24]=3)[C:17]([OH:19])=[O:18])(=[O:11])=[O:12])=[C:7]([CH3:25])[C:6]=2[CH:26]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 66799791HCID 66799791, compound

Product 1

HCID 56941312HCID 56941312, compoundYield 7%

Procedure

The ethyl 3-{[(5-amino-3-methyl-1-benzothien-2-yl)sulfonyl]-amino}benzoate was hydrolyzed with LiOH following the hydrolysis procedure described in Example 46. The title compound was obtained in 7% yield (over two steps, 2.6 mg). MS (ESI+) calcd for C16H14N2O4S2 362.039498, found 362.040938.

Workup

  1. customthe hydrolysis procedure

Sources & evidence

ORD record
ord-3701e103bc544ccc9005ce283e5c63cb
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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