3-Aminobenzoic Acid → HCID 56942027, compound

HRID 589746Notes

Reaction equation

HRID 589746 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([S:11](Cl)(=[O:13])=[O:12])=[C:8]([CH3:15])[C:7]=2[CH:16]=1.[NH2:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21]([OH:23])=[O:22]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([S:11]([NH:17][C:18]3[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=3)[C:21]([OH:23])=[O:22])(=[O:13])=[O:12])=[C:8]([CH3:15])[C:7]=2[CH:16]=1

Participants

3

Reactant 2

HCID 74193-Aminobenzoic AcidHCID 574403395-Methoxy-3-methylbenzo[b]thiophene-2-sulfonyl chloride2×

Product 1

HCID 56942027HCID 56942027, compoundYield 33%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, with 5-methoxy-3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 8) (85 mg, 0.31 mmol) and 3-aminobenzoic acid (42 mg, 0.31 mmol). The title compound was obtained in 33% yield (38.2 mg). MS (ESI+) calcd mass for C17H15NO5S2 377.039164, found 377.039474.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-2691e0699bfa49f5aa4424d3c3d5854d
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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