Trifluoroacetic acid → HCID 118354281, compound

HRID 590574Notes

Reaction equation

HRID 590574 reaction equation
[OH:1][CH2:2][C:3]([CH3:25])([CH3:24])[CH2:4][CH2:5][CH2:6][N:7]1[CH2:22][CH:10]2[CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH2:14][N:9]2[C:8]1=[O:23].C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:1][CH2:2][C:3]([CH3:25])([CH3:24])[CH2:4][CH2:5][CH2:6][N:7]1[CH2:22][CH:10]2[CH2:11][NH:12][CH2:13][CH2:14][N:9]2[C:8]1=[O:23]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118353913HCID 118353913, compound2×

Product 1

HCID 118354281HCID 118354281, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 2-(5-hydroxy-4,4-dimethyl-pentyl)-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazine-7-carboxylate (Compound 69-B) (1 mmol) was dissolved in CH2Cl2 (3 mL) followed by the slow addition of TFA (1 mL) at 0° C. The reaction mixture was stirred at rt for 1 hour and then the solvent was removed under vacuum to give the crude product 69-A, which was used directly in the next step.

Workup

  1. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-d54dc68ca30c4508976d847338453f37
Source dataset
uspto-grants-2016_01
Patent number
US09233978B2

Reaction notes

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