反应详情

温度

100 °C

A mixture of 6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione (1 g, 6.23 mmol), 2,2,2-trifluoroethanol (2.235 mL, 31.14 mmol) and cesium carbonate (6.09 g, 18.68 mmol) in dimethylformamide (10 mL) was heated in a microwave oven at 100° C. for 30 min. The mixture was filtered and the volatiles were removed in vacuum. The residue was treated with diluted HCl (pH 4.5) and cooled to 0° C. The resulting crystals were collected by filtration and dried in vacuum cabinet to yield the title compound, 0.92 g (66%).

1. filtrationThe mixture was filtered
2. customthe volatiles were removed in vacuum
3. additionThe residue was treated with diluted HCl (pH 4.5)
4. temperaturecooled to 0° C
5. filtrationThe resulting crystals were collected by filtration
6. customdried in vacuum cabinet