Hydrochloric Acid → HCID 117823951, compound

HRID 59064Notes

Reaction equation

HRID 59064 reaction equation
C([O:3][C:4]([C:6]1[C:11]([CH3:12])=[C:10]([CH2:13][O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[N:9]=[C:8]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]3)=[C:23]([O:33][CH3:34])[CH:22]=2)[N:7]=1)=[CH2:5])C.Cl.C(=O)(O)[O-].[Na+]>O1CCOCC1.O>[CH3:34][O:33][C:23]1[CH:22]=[C:21]([NH:20][C:8]2[N:7]=[C:6]([C:4](=[O:3])[CH3:5])[C:11]([CH3:12])=[C:10]([CH2:13][O:14][CH2:15][C:16]([F:17])([F:18])[F:19])[N:9]=2)[CH:26]=[CH:25][C:24]=1[N:27]1[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 117824346HCID 117824346, compound

Product 1

HCID 117823951HCID 117823951, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(1-ethoxyvinyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5-methyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-2-amine (52 mg, 0.11 mmol) in dioxane (4 mL), water (0.5 mL) and concentrated hydrochloric acid (0.028 mL, 0.33 mmol) was heated at 40° C. for 35 min. Sodium bicarbonate (40 mg) and water (2 mL) were added. The volatiles were removed in vacuum, the residue was coevaporated with dioxane to give the title compound.

Workup

  1. customThe volatiles were removed in vacuum

Sources & evidence

ORD record
ord-de42a1d0f1e641b2b1d866c1ca1a9ce9
Source dataset
uspto-grants-2016_09
Patent number
US09439904B2

Reaction notes

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