反应详情

A solution of 4-(1-ethoxyvinyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5-methyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-2-amine (52 mg, 0.11 mmol) in dioxane (4 mL), water (0.5 mL) and concentrated hydrochloric acid (0.028 mL, 0.33 mmol) was heated at 40° C. for 35 min. Sodium bicarbonate (40 mg) and water (2 mL) were added. The volatiles were removed in vacuum, the residue was coevaporated with dioxane to give the title compound.

1. customThe volatiles were removed in vacuum