反应详情

温度

160 °C

A mixture of ethyl 3-oxo-4-(2,2,2-trifluoroethoxy)pentanoate (3.29 g, 13.58 mmol) and urea (0.816 g, 13.58 mmol) was heated at 160° C. under nitrogen for 10 h. A solution of potassium carbonate (3.8 g) in water (30 mL) was added and the mixture was extracted with MTBE (20 mL). The aqueous phase was acidified to pH 2 and extracted with MTBE (20 mL). The organic phase was dried over sodium sulfate and concentrated in vacuum to yield the title product, 1.35 g (42%).

1. extractionthe mixture was extracted with MTBE (20 mL)
2. extractionextracted with MTBE (20 mL)
3. dry with materialThe organic phase was dried over sodium sulfate
4. concentrationconcentrated in vacuum