反应详情

温度

60 °C

To a solution of 4-(1-ethoxyvinyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-2-amine (0.418 g, 0.90 mmol) dioxane (60 mL) water 3 mL) and concentrated hydrochloric acid (0.228 mL, 2.71 mmol) were added. The solution was heated at 60° C. for 15 min. The mixture was treated with an excess of sodium bicarbonate and extracted twice with ethyl acetate. The combined organic phase was dried over sodium sulfate and concentrated to yield the title product as a solid 390 mg (99%).

1. extractionextracted twice with ethyl acetate
2. dry with materialThe combined organic phase was dried over sodium sulfate
3. concentrationconcentrated