反应详情

温度

70 °C

Under a nitrogen atmosphere, N-bromosuccinimide (108 mg, 0.6 mmol) was added to a solution of methyl 2-(tert-butoxy)-2-(2-phenyl-1,3-thiazol-4-yl)acetate (6b) (30 mg, 0.1 mmol) in N,N-dimethylformamide (2 mL). The reaction mixture was warmed at 70° C. for 3 hours and ethyl acetate (20 mL) was then added. The organic layer was washed with water (2×10 mL), brine (10 mL), dried over sodium sulfate, filtered, and evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel (cyclohexane/ethyl acetate 80/20) to afford the desired product (6c) as a yellow oil (30 mg, 0.078 mmol, 78%).

1. washThe organic layer was washed with water (2×10 mL), brine (10 mL)
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. customevaporated under reduced pressure
5. customThe residue was purified by flash chromatography on silica gel (cyclohexane/ethyl acetate 80/20)