反应详情

温度

40 °C

4-(1-Ethoxyvinyl)-N-(3-methoxy-4-(4-methoxy-1H-imidazol-1-yl)phenyl)-6-((2,2,2-trifluoro-ethoxy)methyl)pyrimidin-2-amine (0.31 g, 0.65 mmol) was dissolved in dioxane (30 mL) and water (3 mL). Hydrochloric acid (conc., 0.164 mL, 1.94 mmol) was added. The mixture was heated at 40° C. for 35 min. Sodium bicarbonate (1 g) was added. Brine (5 mL) was added and the mixture was extracted with EtOAc (×2). The combined organic phases were dried over sodium sulfate and evaporated to give the title compound as a solid, 0.28 g (98%).

1. extractionthe mixture was extracted with EtOAc (×2)
2. dry with materialThe combined organic phases were dried over sodium sulfate
3. customevaporated