Methylamine → HCID 117821166, compound

HRID 59109Notes

Reaction equation

HRID 59109 reaction equation
[CH3:1][NH2:2].[Cl:3][C:4]1[N:9]=[C:8](Cl)[CH:7]=[C:6]([CH2:11][O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[N:5]=1>CCO.C(#N)C>[Cl:3][C:4]1[N:9]=[C:8]([NH:2][CH3:1])[CH:7]=[C:6]([CH2:11][O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[N:5]=1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 117821043HCID 117821043, compound

Product 1

HCID 117821166HCID 117821166, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6342AcetonitrileSolvent

Conditions

Temperature
0 °C

Procedure

Methanamine (0.124 mL, 0.99 mmol) in EtOH was added to a solution of 2,4-dichloro-6-((cyclopropylmethoxy)methyl)pyrimidine (77 mg, 0.33 mmol) in acetonitrile (6 mL). The mixture was stirred at 0° C. for 30 minutes. The mixture was concentrated and the residue was purified by preparative HPLC give the title compound, 42 mg (56%).

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-cd027a5c0d774abea2aa862d333e9df9
Source dataset
uspto-grants-2016_09
Patent number
US09439904B2

Reaction notes

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