Benzaldehyde → HCID 66746789, compound

HRID 591177Notes

Reaction equation

HRID 591177 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([F:12])=[C:7]([CH:11]=1)[CH2:8][C:9]#[N:10].[O-]CC.[Na+].[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[F:12][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:11][C:7]=1[C:8](=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]#[N:10]

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 2723922Sodium ethoxideHCID 23074300(2-Fluoro-5-methoxyphenyl)acetonitrile

Product 1

HCID 66746789HCID 66746789, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 5-methoxy-2-fluorobenzylcyanide (8 g, 48.4 mmol) in 200 ml ethanol was added sodium ethoxide 21% in ethanol (19.89 ml, 53.3 mmol) and benzaldehyde (4.92 ml, 48.4 mmol). The reaction mixture was stirred at room temperature over night and concentrated to ½ volume, filtered and washed with small amount of ether, and dried under high vacuum to obtain yellow crystals.

Workup

  1. concentrationconcentrated
  2. filtrationfiltered
  3. washwashed with small amount of ether
  4. customdried under high vacuum
  5. customto obtain yellow crystals

Sources & evidence

ORD record
ord-ab18f2cd820a48ca92e659392a7a6009
Source dataset
uspto-grants-2016_01
Patent number
US09238619B2

Reaction notes

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