反应详情

温度

40 °C

4-(1-Ethoxyvinyl)-N-(3-methoxy-4-(6-methylpyridazin-4-yl)phenyl)-6-((2,2,2-trifluoroethoxy)-methyl)pyrimidin-2-amine (65 mg, 0.14 mmol) was dissolved in dioxane (10 mL). Water (0.5 mL) and hydrochloric acid (conc., 0.035 mL, 0.41 mmol) were added. The mixture was heated at 40° C. for 20 min. Sodium bicarbonate (s, 0.5 g) and brine (2 mL) were added and mixture was stirred for 10 min. The mixture was extracted with EtOAC (×2). The organic phase was dried (sodium sulfate) and evaporated to give the title compound as a solid 60 mg (98%).

1. extractionThe mixture was extracted with EtOAC (×2)
2. dry with materialThe organic phase was dried (sodium sulfate)
3. customevaporated