反应详情

To a mixture of tri-n-butylphosphine (7.10 mL), (2,6-dimethylpyridin-3-yl)methanol (3.00 g), ethyl(6-hydroxy-1-benzothiophen-3-yl)acetate (5.43 g) and THF (150 mL) was added ADDP (7.17 g) at room temperature. The mixture was stirred at room temperature under nitrogen atmosphere overnight. The mixture was concentrated. To the residue was added IPE and the precipitate was filtered off. The filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (7.74 g)

1. concentrationThe mixture was concentrated
2. additionTo the residue was added IPE
3. filtrationthe precipitate was filtered off
4. concentrationThe filtrate was concentrated in vacuo
5. customThe residue was purified by silica gel column chromatography (EtOAc/hexane)