反应详情

To a mixture of ethyl(6-((2,6-dimethylpyridin-3-yl)methoxy)-1-benzothiophen-3-yl)acetate (7.73 g), EtOH (75 mL) and THF (dry) (75 mL) was added 1N NaOH (45 mL). The mixture was stirred at room temperature for 2 h. To the mixture were added EtOH (50 mL) and MeOH (75 mL). The mixture was neutralized with 1N HCl (45 mL), and then water (500 mL) was added dropwise to the mixture. The precipitate was collected by filtration and washed with water. The solid was recrystallized from acetone-hexane to give the title compound (4.85 g).

1. filtrationThe precipitate was collected by filtration
2. washwashed with water
3. customThe solid was recrystallized from acetone-hexane