反应详情

To a mixture of tri-n-butylphosphine (0.240 mL), (2,6-dimethylpyridin-3-yl)methanol (92 mg), methyl(6-hydroxy-4,7-dimethyl-1-benzofuran-3-yl)acetate (150 mg) and THF (6.0 mL) was added ADDP (242 mg) at room temperature. The mixture was stirred at room temperature overnight under nitrogen atmosphere. The mixture was concentrated. To the residue was added. IPE and the precipitate was filtered off and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (163.9 mg).

1. concentrationThe mixture was concentrated
2. additionTo the residue was added
3. filtrationIPE and the precipitate was filtered off
4. concentrationthe filtrate was concentrated in vacuo
5. customThe residue was purified by silica gel column chromatography (EtOAc/hexane)